Journal article
Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi
LJ Thompson, SJ Dunstan, C Dolecek, T Perkins, D House, G Dougan, NT Hue, TTP La, DC Du, LT Phuong, NT Dung, TT Hien, JJ Farrar, D Monack, DJ Lynn, SJ Popper, S Falkow
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2009
Abstract
We used microarrays and transcriptional profiling of peripheral blood to investigate the host response of 29 individuals who contracted typhoid fever in the Mekong Delta region of Vietnam. Samples were taken over a nine month period encompassing acute disease, convalescence, and recovery. We found that typhoid fever induced a distinct and highly reproducible signature in the peripheral blood that changed during treatment and convalescence, returning in the majority of cases to the "normal" profile as measured in healthy uninfected controls. Unexpectedly, there was a strong, distinct signature of convalescence present at day 9 after infection that remained virtually unchanged one month after ..
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Funding Acknowledgements
We would like to acknowledge Michael Griffiths, Anna Brotcke, Kate Rubins, Elizabeth Joyce, and Sara Fisher for technical assistance and helpful discussions during this project. Funding assistance was provided by The Ellison Foundation, The Foundation for the National Institutes of Health/Gates Foundation, The Wellcome Trust, and The Deans fellowship at the Stanford School of Medicine (L.J.T.). We are grateful to the directors of the Dong Thap and An Giang Provincial Hospitals and the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, for their support, and we thank all of the doctors and nurses who cared for the patients in this study.