Journal article
A TNF region haplotype offers protection from typhoid fever in Vietnamese patients
SJ Dunstan, NT Hue, K Rockett, J Forton, AP Morris, M Diakite, MN Lanh, LT Phuong, D House, CM Parry, H Vinh, NT Hieu, G Dougan, TT Hien, D Kwiatowski, JJ Farrar
Human Genetics | SPRINGER | Published : 2007
Abstract
The genomic region surrounding the TNF locus on human chromosome 6 has previously been associated with typhoid fever in Vietnam (Dunstan et al. in J Infect Dis 183:261-268, 2001). We used a haplotypic approach to understand this association further. Eighty single nucleotide polymorphisms (SNPs) spanning a 150 kb region were genotyped in 95 Vietnamese individuals (typhoid case/mother/father trios). A subset of data from 33 SNPs with a minor allele frequency of >4.3% was used to construct haplotypes. Fifteen SNPs, which tagged the 42 constructed haplotypes were selected. The haplotype tagging SNPs (T1-T15) were genotyped in 380 confirmed typhoid cases and 380 Vietnamese ethnically matched cont..
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