Journal article
HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam
VP Thao, T Le, EM Török, NTB Yen, TTH Chau, S Jurriaans, HR Van Doorn, MD De Jong, JJ Farrar, SJ Dunstan
Antiviral Therapy | SAGE PUBLICATIONS LTD | Published : 2012
DOI: 10.3851/IMP2098
Abstract
BACKGROUND: Access to antiretroviral therapy (ART) for HIV-infected individuals in Vietnam is rapidly expanding, but there are limited data on HIV drug resistance (HIVDR) to guide ART strategies. METHODS: We retrospectively conducted HIVDR testing in 220 ART-naive individuals recruited to a randomized controlled trial of immediate versus deferred ART in individuals with HIV-associated tuberculous meningitis in Ho Chi Minh City (HCMC) from 2005-2008. HIVDR mutations were identified by population sequencing of the HIV pol gene and were defined based on 2009 WHO surveillance drug resistance mutations (SDRMs). RESULTS: We successfully sequenced 219/220 plasma samples of subjects prior to ART; 21..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by the UK Wellcome Trust (to VPT, TL, EMT, RHvD, MDdJ, JJF and SJD), the US Fogarty International Clinical Research Fellowship and Hawaii Center for AIDS (to TL) and the National Institute of Health Research Cambridge Biomedical Research Centre (to EMT).