Journal article

Pooled analysis of iron-related genes in Parkinson's disease: Association with transferrin

Shannon L Rhodes, Daniel D Buchanan, Ismay Ahmed, Kent D Taylor, Marie-Anne Loriot, Janet S Sinsheimer, Jeff M Bronstein, Alexis Elbaz, George D Mellick, Jerome I Rotter, Beate Ritz

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014

Abstract

Pathologic features of Parkinson's disease (PD) include death of dopaminergic neurons in the substantia nigra, presence of α-synuclein containing Lewy bodies, and iron accumulation in PD-related brain regions. The observed iron accumulation may be contributing to PD etiology but it also may be a byproduct of cell death or cellular dysfunction. To elucidate the possible role of iron accumulation in PD, we investigated genetic variation in 16 genes related to iron homeostasis in three case-control studies from the United States, Australia, and France. After screening 90 haplotype tagging single nucleotide polymorphisms (SNPs) within the genes of interest in the US study population, we investig..

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University of Melbourne Researchers

Grants

Awarded by NIEHS


Awarded by National Health and Medical Research Council


Awarded by Agence Nationale de la Recherche


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Funding Acknowledgements

We are exceptionally grateful to all study participants, whose generosity made this research possible. We thank Drs. Jerome Rotter and Kent Taylor (Cedars-Sinai Medical Center) for their generous support in genotyping the US Study. The US study was funded in part by NIEHS Grants R01-ES010544, U54-E5012078, P01-ES016732; the Michael J. Fox Foundation; The Parkinson Alliance; the American Parkinson Disease Association; and the Veterans Administration Healthcare System (SW PADRECC). The Australian study would like to acknowledge the support of the Geriatric Medical Foundation of Queensland, the National Health and Medical Research Council (grant #401537), and Parkinson's Queensland Incorporated. The French study was funded by the Agence Nationale de la Recherche (grant ANR-09-MNPS-012-01). The funding organizations had no role in the design, conduct, interpretation, or publication of this work.