Processing Speed, Attention, and Working Memory After Treatment for Medulloblastoma: An International, Prospective, and Longitudinal Study
Shawna L Palmer, Carol Armstrong, Arzu Onar-Thomas, Shengjie Wu, Dana Wallace, Melanie J Bonner, Jane Schreiber, Michelle Swain, Lynn Chapieski, Donald Mabbott, Sarah Knight, Robyn Boyle, Amar Gajjar
JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2013
PURPOSE: The current study prospectively examined processing speed (PS), broad attention (BA), and working memory (WM) ability of patients diagnosed with medulloblastoma over a 5-year period. PATIENTS AND METHODS: The study included 126 patients, ages 3 to 21 years at diagnosis, enrolled onto a collaborative protocol for medulloblastoma. Patients were treated with postsurgical risk-adapted craniospinal irradiation (n = 36 high risk [HR]; n = 90 average risk) followed by four cycles of high-dose chemotherapy with stem-cell support. Patients completed 509 neuropsychological evaluations using the Woodcock-Johnson Tests of Cognitive Abilities Third Edition (median of three observations per patie..View full abstract
Awarded by National Cancer Institute through a Cancer Center Support grant
Awarded by NATIONAL CANCER INSTITUTE
Supported, in part, by the National Cancer Institute through a Cancer Center Support grant (Grant No. P30-CA21765), the Noyes Brain Tumor Foundation, Musicians Against Childhood Cancer, and the American Lebanese Syrian Associated Charities.