GABAB receptors depress glutamate release at C-fiber afferent synapses in the nucleus of the solitary tract (NTS)

Abstract

Cranial visceral primary afferents follow the solitary tract (ST) to synapse on 2 nd order NTS neurons. These afferents consist of both A‐fibers (transient receptor potential vanilloid receptor negative (TRPV1 − )) and C‐fibers (TRPV1 + ). The inhibitory transmitter GABA acts ionotropically at GABA A and metabotropically at GABA B receptors. In horizontal hindbrain slices, ST shocks evoked time‐invariant glutamatergic EPSCs with jitters <200 μs at 2 nd ..