ZSWIM1: A novel biomarker in T helper cell differentiation
K Kerry Ko, Maree S Powell, P Mark Hogarth
IMMUNOLOGY LETTERS | ELSEVIER SCIENCE BV | Published : 2014
The effector memory CD4+ Th17 cells play critical roles in bacterial immunity and pathological inflammation in autoimmune conditions. ZSWIM1 is a gene encoding a protein of unknown function in leukocytes-but containing a zinc finger SWIM motif. In peripheral blood mononuclear cells, the expression of ZSWIM1 is highest in lymphocytes, and in particular shows greatest abundance in naive CD4+ T cells. Upon polarisation of naïve CD4+ T cells, ZSWIM1 expression is retained in Th17 cells but is selectively down regulated in Th1 cells. Similarly in in vitro expanded effector memory CD4+ T cells, ZSWIM1 was more abundant in Th17 cells compared to Th1 or Th17 polyfunctional (Th17pf) cells, which prod..View full abstract
We would like to acknowledge Ms Eva Orlowski for technical assistance, and Dr Bruce Wines and Ms Halina Trist for helpful suggestions. This work was funded by National Health and Research Council Project grants and the Victorian Operational Infrastructure Scheme. KK was supported by Zimmer Australia (Arthritis Australia) and the Collaborative Research Centre for Biomarker Translation.