Journal article

The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells

Sagie Wagage, Beena John, Bryan L Krock, Aisling O'Hara Hall, Louise M Randall, Christopher L Karp, M Celeste Simon, Christopher A Hunter

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2014

Abstract

The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In the present studies, an IL-10 reporter mouse was used to identify the sources of this cytokine following challenge with Toxoplasma gondii. During infection, multiple cell types expressed the IL-10 reporter but NK cells were a major early source of this cytokine. These IL-10 reporter(+) NK cells expressed high levels of the IL-12 target genes T-bet, KLRG1, and IFN-γ, and IL-12 depletion abrogated reporter expression. However, IL-12 signaling alone was not sufficient to promote NK cell IL-10, and activation of the aryl hydrocarbon receptor (AHR) was also required for maximal IL-10 pr..

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University of Melbourne Researchers