Journal article
Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs
GR Polglase, DG Tingay, R Bhatia, CA Berry, RJ Kopotic, CP Kopotic, Y Song, E Szyld, AH Jobe, JJ Pillow
BMC Pediatrics | Published : 2014
Abstract
Background: Sustained inflations (SI) are advocated for the rapid establishment of FRC after birth in preterm and term infants requiring resuscitation. However, the most appropriate way to deliver a SI is poorly understood. We investigated whether a volume-limited SI improved the establishment of FRC and ventilation homogeneity and reduced lung inflammation/injury compared to a pressure-limited SI.Methods: 131 d gestation lambs were resuscitated with either: i) pressure-limited SI (PressSI: 0-40 cmH2O over 5 s, maintained until 20 s); or ii) volume-limited SI (VolSI: 0-15 mL/kg over 5 s, maintained until 20 s). Following the SI, all lambs were ventilated using volume-controlled ventilation (..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
This research was supported by an unrestricted research grant from Fisher & Paykel Healthcare, the Women and Infants Research Foundation, NICHD 12714 (AHJ) and Fundasamin-Fundacion para la Salud Materno Infantil (ES). Investigator fellowship support was provided by a Sylvia and Charles Viertel Senior Medical Research Fellowship (JJP) and a NH&MRC Fellowship (GRP: 1026890, DGT: 491286). Radiant warmer beds were provided by Fisher & Paykel Healthcare T (Auckland, NZ). Essential blood gas analysis equipment was accessed via an NHMRC Equipment Grant. DGT and GRP are supported by the Victorian Government Operational Infrastructure Support Program. JJP's research program is supported by the WA Government Medical and Health Research Infrastructure Fund.