ARX/Arx is expressed in germ cells during spermatogenesis in both marsupial and mouse
Hongshi Yu, Andrew J Pask, Yanqiu Hu, Geoff Shaw, Marilyn B Renfree
REPRODUCTION | BIOSCIENTIFICA LTD | Published : 2014
The X-linked aristaless gene, ARX, is essential for the development of the gonads, forebrain, olfactory bulb, pancreas, and skeletal muscle in mice and humans. Mutations cause neurological diseases, often accompanied by ambiguous genitalia. There are a disproportionately high number of testis and brain genes on the human and mouse X chromosomes. It is still unknown whether the X chromosome accrued these genes during its evolution or whether genes that find themselves on the X chromosome evolve such roles. ARX was originally autosomal in mammals and remains so in marsupials, whereas in eutherian mammals it translocated to the X chromosome. In this study, we examined autosomal ARX in tammars a..View full abstract
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This study was supported by the Australian Research Council Centre of Excellence in Kangaroo Genomics, a Federation Fellowship to M B Renfree, and a National Health and Medical Research Council R D Wright Fellowship to A J Pask, and an NHMRC project grant to M B Renfree, G Shaw, and A J Pask.