Journal article
High-resolution in vivo imaging of bone and joints: A window to microarchitecture
P Geusens, R Chapurlat, G Schett, A Ghasem-Zadeh, E Seeman, J De Jong, J Van Den Bergh
Nature Reviews Rheumatology | Published : 2014
Abstract
Imaging is essential to the evaluation of bone and joint diseases, and the digital era has contributed to an exponential increase in the number of publications on noninvasive analytical techniques for the quantification of changes to bone and joints that occur in health and in disease. One such technique is high-resolution peripheral quantitative CT (HR-pQCT), which has introduced a new dimension in the imaging of bone and joints by providing images that are both 3D and at high resolution (82 μm isotropic voxel size), with a low level of radiation exposure (3-5 μSv). HR-pQCT enables the analysis of cortical and trabecular properties separately and to apply micro-finite element analysis for c..
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Funding Acknowledgements
P.G. is the coordinator of clinical studies with high-resolution peripheral quantitative CT (HR-pQCT) for which Maastricht University Medical Centre received grants from Amgen, Pfizer and Will Pharma. R. C. has been a consultant, speaker, or clinical investigator with the following companies: Amgen, Bioiberica, BMS, Chugai, Lilly, Merck, Novartis, Novo, Pfizer, Servier and UCB; R. C. has no direct or indirect link to the manufacturer of HR-pQCT. A.G.-Z. is one of the inventors of StrAx1.0, an algorithm used to quantify bone microstructure. E. S. is Director of StraxCorp and one of the inventors of StrAx1.0. G. S., J.d.J, and J.v.d.B. declare no competing interests.