Journal article

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

Leila N Varghese, Daniela Ungureanu, Nicholas PD Liau, Samuel N Young, Artem Laktyushin, Henrik Hammaren, Isabelle S Lucet, Nicos A Nicola, Olli Silvennoinen, Jeffrey J Babon, James M Murphy

Biochemical Journal | PORTLAND PRESS LTD | Published : 2014

Grants

Awarded by NHMRC (National Health and Medical Research Council)


Awarded by National Institutes of Health


Awarded by ARC (Australian Research Council) fellowships


Awarded by NHMRC IRIISS (Victorian State Government Operational Infrastructure Support)


Awarded by Novo Nordisk Fonden


Funding Acknowledgements

This work was supported by the NHMRC (National Health and Medical Research Council) [grant numbers 1011 804 and 1016647], the National Institutes of Health [grant number CA-22556]; Leukaemia Foundation and Australian Stem Cell Centre scholarships (to L.N.V.); an NHMRC fellowship (to N.A.N.), ARC (Australian Research Council) fellowships [grants FT110100169 and FT100100100 (to J.J.B. and J M.M)]; the Medical Research Council of Academy of Finland, the Sigrid Juselius Foundation, the Medical Research Fund of Tampere University Hospital, the Finnish Cancer Foundation and the Tampere Tuberculosis Foundation (to U.S.). There was additional support from the Victorian State Government Operational Infrastructure Support and NHMRC IRIISS (Victorian State Government Operational Infrastructure Support) [grant number 361646].