Correlation of p16 status, hypoxic imaging using [18F]-misonidazole positron emission tomography and outcome in patients with loco-regionally advanced head and neck cancer
Mateya E Trinkaus, Rodney J Hicks, Richard J Young, Lester J Peters, Ben Solomon, Mathias Bressel, June Corry, Richard Fisher, David Binns, Grant A McArthur, Danny Rischin
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY | WILEY | Published : 2014
INTRODUCTION: We investigated the relationship between hypoxia, human papillomavirus (HPV) status and outcome in head and neck squamous cell carcinoma. METHODS: Patients with stage III and IV head and neck squamous cell carcinoma treated on phase I and II chemoradiation trials with 70-Gy radiation combined with tirapazamine/cisplatin or cisplatin/fluorouracil (5FU), hypoxic imaging using [18F]-misonidazole positron emission tomography and known HPV status (by p16 immunohistochemistry) were included in this sub-study. Separate analyses were conducted to consider the impact of tirapazamine on HPV-negative tumours in the phase II trial. RESULTS: Both p16-positive oropharyngeal tumours and p16-n..View full abstract
This project was supported by a National Health and Medical Research Council (NHMRC) grant and a Canadian Institutes of Health Research (CIHR) fellowship.