Journal article
Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women
CKZ Chua, VW Henderson, L Dennerstein, D Ames, C Szoeke
Neurobiology of Aging | ELSEVIER SCIENCE INC | Published : 2014
Abstract
The association between serum dehydroepiandrosterone sulfate (DHEAS) and cognition was assessed in 218 healthy, midlife, post-menopausal women, aged 55-65years. In cross-sectional analyses, DHEAS level was not significantly associated with a standardized score of global cognition or with individual test scores from a comprehensive neuropsychological battery (all p-values >0.05). In longitudinal analyses of 176 women, DHEAS level was unassociated with cognition 2years later or with 2-year change in cognition. These findings fail to support the view that DHEAS is substantially related to cognitive function in midlife, post-menopausal women. © 2014 Elsevier Inc.
Grants
Awarded by Alzheimer's Association
Funding Acknowledgements
This study has been partly supported by the Brain Foundation, Alzheimer's Association of Australia, Alzheimer's Association (IIRG-01-2684), Australian Menopausal Society, Shepherd Foundation, Scobie and Claire McKinnon Foundation, Collier Trust Fund, Ramaciotti Foundation, Bayer Pharmaceuticals, J.O. & J.R. Wicking Trust, and the National Health and Medical Research Council. The authors are indebted to the women in the project, who generously donated their time to participate in this research study.