Journal article

Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

Paul V Licciardi, Fiona M Russell, Anne Balloch, Robert L Burton, Moon H Nahm, Gwendolyn Gilbert, Mimi LK Tang, Edward K Mulholland

VACCINE | ELSEVIER SCI LTD | Published : 2014

Abstract

The impact of prior nasopharyngeal carriage on serotype-specific IgG responses following immunization with pneumococcal conjugate vaccines (PCV) has recently been described. This report extends these findings to describe the attenuation of functional immune responses following 23-valent pneumococcal polysaccharide vaccination (PPS). We report the attenuation of immune responses following booster with the 23-valent pneumococcal polysaccharide vaccination (PPS) in infants with prior nasopharyngeal carriage of Streptococcus pneumoniae. Fijian infants who were part of a phase II randomized, controlled trial of reduced dose PCV7 schedules were the basis of this study. Pneumococcal carriage was de..

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Grants

Awarded by National Institute of Allergy and Infectious Diseases (NIAID)


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

Funding source: This work was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID; 2 U01 AI052337-05), the Australian National Health and Medical Research Council (NHMRC grant no. 251648), and the Victorian Government's Operational Infrastructure Support Program. Pneumovax was kindly donated by CSL Biotherapies, Australia. P.V.L. is a recipient of an NHMRC Training Fellowship. M.H.N. is supported by National Institutes of Health contract AI-30021.