Journal article

In Vivo Histologically Equivalent Evaluation of Gastric Mucosal Topologic Morphology in Dogs By using Confocal Endomicroscopy

MJ Sharman, B Bacci, T Whittem, CS Mansfield

Journal of Veterinary Internal Medicine | WILEY | Published : 2014


BACKGROUND: Confocal endomicroscopy (CEM) is an endoscopic technology permitting in vivo cellular and subcellular imaging. CEM aids real-time clinical assessment and diagnosis of various gastrointestinal diseases in people. CEM allows in vivo characterization of small intestinal mucosal morphology in dogs. OBJECTIVE: To determine the feasibility of CEM to evaluate gastric mucosal morphology in dogs and to characterize the appearance in healthy dogs. ANIMALS: Fourteen clinically healthy research colony dogs. METHODS: Experimental study. Under general anesthesia, dogs underwent standard endoscopic evaluation and CEM of the gastric mucosa. In the initial 6 dogs, fluorescent contrast was provide..

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Funding Acknowledgements

The study was supported, in part, by grants from the Comparative Gastroenterology Society Waltham's Research grant and by the Victorian Government's Operational Infrastructure Support Program. The confocal endomicroscope was purchased by the University of Melbourne and the Victorian Department of Business and Innovation; Victorian Science Agenda. This equipment forms part of the Victorian Biomedical Imaging Capability.