Journal article
Pandemic H1N1 virus transmission and shedding dynamics in index case households of a prospective Vietnamese cohort
PQ Thai, LQ Mai, MRA Welkers, NLK Hang, LT Thanh, VTV Dung, NTT Yen, TN Duong, LNM Hoa, DD Thoang, HTH Trang, MD de Jong, H Wertheim, NT Hien, P Horby, A Fox
Journal of Infection | Published : 2014
Abstract
Objectives: Influenza household transmission studies are required to guide prevention strategies but most passively recruit index cases that seek healthcare. We investigated A(H1N1)pdm09 transmission in a household-based cohort during 2009. Methods: Health-workers visited 270 households weekly, and collected swabs from influenza-like-illness cases. If A(H1N1)pdm09 was RT-PCR-confirmed, all household members had symptoms assessed and swabs collected daily for 10-15 days. Viral RNA was quantified and sequenced and serology performed on pre-pandemic sera. Results: Index cases were detected in 20 households containing 81 people. 98.5% lacked A(H1N1)pdm09 neutralizing antibodies in pre-pandemic s..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
[ "We are grateful to the community of An Hoa Commune for agreeing to participate in this study and for providing their time. We would like to thank the hamlet health workers who conducted the interviews and surveillance. We also wish to thank the Ministry of Health of Vietnam for their continuing support of the research collaboration between the Oxford University Clinical Research Unit and the National Institute for Hygiene and Epidemiology.", "This work was supported by the Wellcome Trust UK (grants 081613/Z/06/Z and 077078/Z/05/Z). AF was supported by the European Union FP7 project \" European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE)\" (no. 223498)." ]