Journal article

Advantages and pitfalls in the application of mixed-model association methods

Jian Yang, Noah A Zaitlen, Michael E Goddard, Peter M Visscher, Alkes L Price

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2014

University of Melbourne Researchers

Grants

Awarded by US National Institutes of Health (NIH)


Awarded by Australian Research Council


Awarded by Australian National Health and Medical Research Council


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

We are grateful to N. Patterson, D. Heckerman, J. Listgarten, C. Lippert, E. Eskin, B. Vilhjalmsson, P. Loh, T. Hayeck, T. Frayling, A. McRae, L. Ronnegard, O. Weissbrod, G. Tucker and the GIANT Consortium for helpful discussions and to A. Gusev and S. Pollack for assistance with the multiple sclerosis and ulcerative colitis data sets. We are grateful to two anonymous referees for their helpful comments. This study makes use of data generated by the Wellcome Trust Case Control Consortium and data from the database of Genotypes and Phenotypes (dbGaP) under accessions phs000090.v2.p1 and phs000091.v2.p1 (see the Supplementary Note for the full set of acknowledgments for these data). This research was supported by US National Institutes of Health (NIH) grants R01 HG006399, P01 GM099568 and R01 GM075091, by the Australian Research Council (DP130102666) and by the Australian National Health and Medical Research Council (APP1011506 and APP1052684).