Comparison of contemporary methods for estimating prostate tumour volume in pathological specimens

Abstract

Objective To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice. Patients and Methods Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between September 2009 and May 2011. Tumour properties including thickness, width and length were collected and TV was established using computer-assisted image analysis (CAIA). TV estimation methods including; square, cuboidal and ellipsoidal estimations were calculated using previously reported formulae. The estimation methods were compared against the 'gold-standard' and the accuracy of ide..