Journal article

Randomised controlled trials in child health in developing countries: trends and lessons over 11 years

Trevor Duke, David Fuller

Archives of Disease in Childhood | BMJ PUBLISHING GROUP | Published : 2014


Using a uniform systematic approach annually, we reviewed 1553 publications from randomised controlled trials in child health in developing countries published between July 2002 and June 2013. There were annual increases in such publications, from 38 in the 12 months to July 2003 to over 200 in each of 2012 and 2013. These trials involved children in 76 developing countries. Studies of nutrition (366 publications, 23.6%) and malaria (336 publications, 21%) predominated. 79% of nutrition trials have been of micronutrients (288 publications), with comparatively few publications related to macronutrient interventions or complimentary feeding (48 publications) or measures to improve breast feedi..

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Funding Acknowledgements

The Centre for International Child Health received funding through AusAID as part of the Knowledge Hubs for Health Initiative, and is a WHO Collaborating Centre for Research and Training in Child and Neonatal Health. The authors are grateful to the RE Ross Trust (Victoria) for funding support.