Journal article

Auditory responses to electric and infrared neural stimulation of the rat cochlear nucleus

Rohit U Verma, Amelie A Guex, Kenneth E Hancock, Nedim Durakovic, Colette M McKay, Michael CC Slama, M Christian Brown, Daniel J Lee

HEARING RESEARCH | ELSEVIER | Published : 2014

Abstract

In an effort to improve the auditory brainstem implant, a prosthesis in which user outcomes are modest, we applied electric and infrared neural stimulation (INS) to the cochlear nucleus in a rat animal model. Electric stimulation evoked regions of neural activation in the inferior colliculus and short-latency, multipeaked auditory brainstem responses (ABRs). Pulsed INS, delivered to the surface of the cochlear nucleus via an optical fiber, evoked broad neural activation in the inferior colliculus. Strongest responses were recorded when the fiber was placed at lateral positions on the cochlear nucleus, close to the temporal bone. INS-evoked ABRs were multipeaked but longer in latency than tho..

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Awarded by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS


Funding Acknowledgements

Supported by the Helene and Grant Wilson Auditory Brainstem Implant Program at the Massachusetts Eye and Ear Infirmary, a Med-EL Hearing Solutions Research Grant, the Bertarelli Foundation, NIH grant DC01089, and the Paul and Daisy Soros Fellowship for New Americans. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. We thank Lockheed-Martin for supplying the Aculite laser, and Ishmael Stefanov, Evan Foss, and Haobing Wang for technical assistance. Preliminary versions of this work were presented at the 2012 meeting of the Association for Research in Otolaryngology and are contained in a master's thesis (Guex, 2012).