Journal article
PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity
O Gilan, J Diesch, M Amalia, K Jastrzebski, AC Chueh, NM Verrills, RB Pearson, JM Mariadason, E Tulchinsky, RD Hannan, AS Dhillon
Oncogene | Published : 2015
DOI: 10.1038/onc.2014.26
Abstract
The proto-oncogene c-Jun is a component of activator protein-1 (AP-1) transcription factor complexes that regulates processes essential for embryonic development, tissue homeostasis and malignant transformation. Induction of gene expression by c-Jun involves stimulation of its transactivation ability and upregulation of DNA binding capacity. While it is well established that the former requires JNK-mediated phosphorylation of S63/S73, the mechanism(s) through which binding of c-Jun to its endogenous target genes is regulated remains poorly characterized. Here we show that interaction of c-Jun with chromatin is positively regulated by protein phosphatase 2A (PP2A) complexes targeted to c-Jun ..
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Funding Acknowledgements
We thank Drs David Gillespie, Eisuke Nishida, Chunming Liu, Kanaga Sabapathy and William Kaelin for providing reagents used in this study. This work was supported by project grants (to ASD and RDH) and Research Fellowships (to RDH, RBP and JMM) from the National Health and Medical Research Council of Australia and the Cancer Institute NSW (to NMV).