Vancomycin therapeutics and monitoring: a contemporary approach
ML Avent, VL Vaska, BA Rogers, AC Cheng, SJ van Hal, NE Holmes, BP Howden, DL Paterson
INTERNAL MEDICINE JOURNAL | WILEY | Published : 2013
Vancomycin remains a clinically useful antibiotic despite the advent of several alternative drugs. Optimising vancomycin therapy with therapeutic drug monitoring is widely recommended. The aim of therapeutic drug monitoring is to help the clinician to achieve target pharmacodynamic parameters in the case of vancomycin, an area under the concentration time curve/minimum inhibitory concentration ratio of ≥400. Vancomycin monitoring methods can be categorised into four categories: empiric trough concentrations; linear regression analysis (one-compartment model), population methods and Bayesian estimation procedures. Although the empiric trough concentrations and population methods are easy to u..View full abstract
Ben Rogers is supported by a postgraduate scholarship from the University of Queensland and Allen Cheng by a NHMRC Career Development Fellowship. Natasha Holmes is supported by an NHMRC Postgraduate Scholarship. Benjamin Howden is supported by a NHMRC Career Development Fellowship.