Cognitive Deficits In Friedreich Ataxia Correlate with Micro-structural Changes in Dentatorubral Tract
Hamed Akhlaghi, Johnson Yu, Louise Corben, Nellie Georgiou-Karistianis, John L Bradshaw, Elsdon Storey, Martin B Delatycki, Gary F Egan
CEREBELLUM | SPRINGER | Published : 2014
Atrophy of the dentate nucleus is one of the major neuropathological changes in Friedreich ataxia (FRDA). Neuroimaging studies demonstrated white matter (WM) degeneration in FRDA. In this study, we used advanced tractography techniques to quantitatively measure WM changes in the dentato-thalamic and dentato-rubral tracts, and correlated these changes with cognitive profiles of FRDA. We also analysed diffusivity changes of the thalamo-cortical tract to assess whether neurological degeneration of WM extends beyond the primary site of involvement in FRDA. Twelve genetically proven individuals with FRDA and 14 controls were recruited. Sixty directions diffusion tensor images were acquired. The W..View full abstract
Friedreich Ataxia Research Association (Australasia), Friedreich Ataxia Research Alliance (USA) and Murdoch Childrens Research Institute. HA received a Melbourne International Fee Remission Scholarship and a Melbourne International Research Scholarship. GFE is an NHMRC Principal Research Fellow (#1003993).