Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation
Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, Anthony R White
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
Abnormal biometal homeostasis is a central feature of many neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease. Recent studies have shown that metal complexing compounds behaving as ionophores such as clioquinol and PBT2 have robust therapeutic activity in animal models of neurodegenerative disease; however, the mechanism of neuroprotective action remains unclear. These neuroprotective or neurogenerative processes may be related to the delivery or redistribution of biometals, such as copper and zinc, by metal ionophores. To investigate this further, we examined the effect of the bis(thiosemicarbazonato)-copper complex, Cu(II)(gts..View full abstract
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This work was supported by grants from the ANZ Trustees Wicking Foundation and Mason Trust, the Brain Foundation of Australia, Australian Research Council (ARC) and National Health and Medical Research Council of Australia (NHMRC). ARW is a recipient of an ARC Future Fellowship. RC is an NHMRC Senior Research Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.