De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-X-L: Synthesis, Structural and Biochemical Characterization
Ryan M Brady, Amelia Vom, Michael J Roy, Nathan Toovey, Brian J Smith, Rebecca M Moss, Effie Hatzis, David CS Huang, John P Parisot, Hong Yang, Ian P Street, Peter M Colman, Peter E Czabotar, Jonathan B Baell, Guillaume Lessene
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2014
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Leukemia and Lymphoma Society (Specialized Center of Research Grants)
Awarded by Cancer Council of Victoria
Awarded by NHMRC Independent Research Institutes Infrastructure Support Scheme Grant
We thank our colleagues at WEHI for their work on the BCL-2 family of proteins that has led to this contribution and for discussions during this work, in particular, Andreas Strasser and Suzanne Cory. This work was supported by fellowships and grants from the Australian Research Council (fellowship to P.E.C.), the National Health and Medical Research Council (NHMRC, fellowships to J.B.B. and P.M.C.; Project Grant GNT1025138; Development Grant 305536; and Program Grants 257502, 461221, and 1016701), the Leukemia and Lymphoma Society (Specialized Center of Research Grants 7015 and 7413), the Cancer Council of Victoria (fellowship to P.M.C., Grant-in-Aid 461239), and the Australian Cancer Research Foundation. Infrastructure support from the NHMRC Independent Research Institutes Infrastructure Support Scheme Grant 361646 and a Victorian State Government OIS grant are gratefully acknowledged.