Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity

James I MacRae; Sash Lopaticki; Alexander G Maier; Thusitha Rupasinghe; Amsha Nahid; Alan F Cowman; Malcolm J McConville

Journal article

Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity

James I MacRae, Sash Lopaticki, Alexander G Maier, Thusitha Rupasinghe, Amsha Nahid, Alan F Cowman, Malcolm J McConville

MOLECULAR MICROBIOLOGY | WILEY | Published : 2014

DOI: 10.1111/mmi.12496

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University of Melbourne Researchers

Malcolm McConville Author Biochemistry and Molecular Biology

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Metabolomic analysis of malaria and antimalarial drugs

There is an urgent need to develop new drugs to treat malaria, one of the most important diseases to afflict humanity. We have developed new..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

We thank Ms Monica Brown at the Walter and Eliza Hall Institute of Medical Research for technical assistance, Professor Andrew Holmes for providing authentic myo-inositol 3-phosphate, Dr Maria Doyle (Melbourne University) for discussions, and the Australian Red Cross Blood service (Melbourne), for provision of serum. This work was supported by program (APP406601) and project (APP1006024) grants and the Independent Research Institute Infrastructure Support Scheme from the National Health and Medical Research Council of Australia (NHMRC) and the Victorian State Government Operational Infrastructure Support Scheme. J.I.M. was supported by a Royal Society Travelling Fellowship. M.J.M. is an NHMRC Principal Research Fellow. A.F.C. is an International Scholar of the Howard Hughes Medical Institute. A.G.M. is an ARC Australian Research Fellow. None of the authors have a conflict of interest with the work reported in this study.