Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites
James S Pham, Karen L Dawson, Katherine E Jackson, Erin E Lim, Charisse Flerida A Pasaje, Kelsey EC Turner, Stuart A Ralph
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2014
Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the charged tRNAs needed for appropriate construction of peptide chains. These enzymes have long been pursued as drug targets in bacteria and fungi, but the past decade has seen considerable research on aminoacyl-tRNA synthetases in eukaryotic parasites. Existing inhibitors of bacterial tRNA synthetases have been adapted for parasite use, novel inhibitors have been developed against parasite enzymes, and tRNA synthetases have been identified as the targets for compounds in use or development as antiparasitic drugs. Crystal structures have now been solved for many parasite tRNA synthetases, and opportunities for ..View full abstract
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Awarded by Australian Research Council Future Fellowship
JSP is supported by an Australian Postgraduate Award. KEJ is supported by a CASS foundation grant. SAR is supported by an Australian Research Council Future Fellowship (FT0990350).