Optimal strategies for identifying kidney disease in diabetes: Properties of screening tests, progression of renal dysfunction and impact of treatment - Systematic review and modelling of progression and cost-effectiveness

Abstract

Background: Annual screening for adults with type 2 diabetes to detect the early onset of kidney disease is widely recommended, but the recommendations are based on a limited methodological approach. In addition, there are continuing uncertainties about underlying rates of progression of the condition and the benefits of treatments with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Objectives: We aimed to estimate the clinical value and cost-effectiveness of different screening intervals to diagnose early diabetic kidney disease. Data sources: We used the following databases for the literature review (searched January 2005 to August 2010): MEDLINE, EMBASE and th..