Journal article
Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity
GM O'Connor, JP Vivian, JM Widjaja, JS Bridgeman, E Gostick, BAP Lafont, SK Anderson, DA Price, AG Brooks, J Rossjohn, DW McVicar
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2014
Abstract
Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating variants within the Bw4 motif. Genetic studies suggest that KIR3DL1 variation has functional significance in several disease states, including HIV infection. However, owing to differences across KIR3DL1 allotypes, HLABw4, and associated peptides, the mechanistic link with biological outcome remains unclear. In this study, we elucidated the impact of KIR3DL1 polymorphism on peptide-laden HLA recognition...
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Awarded by Association for International Cancer Research
Funding Acknowledgements
This work was supported by the Intramural AIDS Targeted Antiviral Program of the National Institutes of Health, the National Health and Medical Research Council of Australia, the Association for International Cancer Research (to A. G. B. and J.R.), and the Intramural Research Program of the National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, and federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under Contract HHSN26120080001E. J.P.V. is an Australian Research Council Discovery Early Career Researcher Award Fellow, D. A. P. is a Wellcome Trust Senior Investigator, and J.R. is a National Health and Medical Research Council of Australia Fellow.