Journal article

Epistatic Interactions between Apolipoprotein E and Hemoglobin S Genes in Regulation of Malaria Parasitemia

V Rougeron, CM Woods, KE Tiedje, F Bodeau-Livinec, F Migot-Nabias, P Deloron, AJF Luty, FJI Fowkes, KP Day

PLoS ONE | Published : 2013

Abstract

Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). Given that cholesterol is an important nutrient for malaria parasites, we examined whether APOE Ɛ4 was a risk factor for Plasmodium infection, in terms of prevalence or parasite density. A cross sectional survey was performed in 508 children aged 1 to 12 years in Gabon during the wet season. Children were screened for Plasmodium spp. infection, APOE and hemoglobin S (HbS) polymorph..

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Grants

Awarded by Wellcome Trust Programme


Awarded by European Union INCO Programme


Awarded by NIH/National Institute of Allergy and Infectious Disease


Awarded by NIH Ruth L. Kirschstein National Research Service Award Individual Fellowship


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

FJIF and KPD received financial support from the Wellcome Trust Programme (grant No. 041354) and FMN, PD, AJFL and KPD received support from the European Union INCO Programme (contract no. IC18-CT98-0359). VR, KET and KPD were supported by a grant from NIH/National Institute of Allergy and Infectious Disease grant (R01-AI-084156). CMW was a recipient of a NIH Ruth L. Kirschstein National Research Service Award Individual Fellowship (F31-GM-86134). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.