Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

C Kim-Fuchs; CP Le; MA Pimentel; D Shackleford; D Ferrari; E Angst; F Hollande; EK Sloan

Journal article

Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

C Kim-Fuchs, CP Le, MA Pimentel, D Shackleford, D Ferrari, E Angst, F Hollande, EK Sloan

Brain Behavior and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014

DOI: 10.1016/j.bbi.2014.02.019

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Abstract

Pancreatic cancer cells intimately interact with a complex microenvironment that influences pancreatic cancer progression. The pancreas is innervated by fibers of the sympathetic nervous system (SNS) and pancreatic cancer cells have receptors for SNS neurotransmitters which suggests that pancreatic cancer may be sensitive to neural signaling. In vitro and non-orthotopic in vivo studies showed that neural signaling modulates tumour cell behavior. However the effect of SNS signaling on tumor progression within the pancreatic microenvironment has not previously been investigated. To address this, we used in vivo optical imaging to non-invasively track growth and dissemination of primary pancrea..

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University of Melbourne Researchers

Frederic Hollande Author

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Funding Acknowledgements

The authors thank Mr Ming Chai for preparing the cell lines, Dr Kouki Morizono for luciferase expression vectors, Ms Annja Winter for human tissue staining, Dr Anna Cook and Dr Chris Langmead for guidance with cAMP assays, Dr Francis Chiu for UPLC-MS analysis and Dr Sarah Creed, Dr Jonathan Hiller and Dr Phoebe Phillips for thoughtful discussion of this research. This work was supported by the Australian National Health and Medical Research Council (1008865, 1049561), the Australian Research Council (LE1 10100125), and the National Cancer Institute (CA160890). Dr Corina Kim-Fuchs is supported by a fellowship from the Swiss Cancer League and an HDR scholarship from Monash University. Ms Caroline Le is supported by an Australian Postgraduate Award and a PhD scholarship from the Co-operative Research Centre for Cancer Therapeutics. Dr Eliane Angst is supported by a grant from the Bern Cancer League. Dr Erica Sloan is supported by an Early Career Fellowship from the National Breast Cancer Foundation.