Journal article
Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor
JH Kim, C Perry, S Luikinga, I Zbukvic, RM Brown, AJ Lawrence
Addiction Biology | Published : 2015
DOI: 10.1111/adb.12142
Abstract
We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly imp..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Funding Acknowledgements
This research was supported by a project grant (APP1022201) from the National Health and Medical Research Council (NHMRC) of Australia awarded to A.J.L. and J.H.K., the Australian Research Council Fellowship awarded to J.H.K., and the NHMRC Fellowships awarded to A.J.L. and R.M.B. We acknowledge the Victorian Government's Operational Infrastructure Support Program. We would like to thank the Florey Behaviour Core Facility.