Endocytic Capsule Sensors for Probing Cellular Internalization

K Liang; ST Gunawan; JJ Richardson; GK Such; J Cui; F Caruso

Journal article

Endocytic Capsule Sensors for Probing Cellular Internalization

K Liang, ST Gunawan, JJ Richardson, GK Such, J Cui, F Caruso

Advanced Healthcare Materials | Published : 2014

DOI: 10.1002/adhm.201400139

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Abstract

A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reversible "on/off" fluorescence in response to cellular pH variations. Using this system, the high-throughput quantification between surface-bound and internalized capsules is demonstrated. This system allows a fundamental study of the interaction between nanoengineered materials and biological systems at a cellular level.

University of Melbourne Researchers

Georgina Such Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F. C., 120100030), Discovery Project (F. C., 130101846), Super Science (F. C., FS110200025), and Future Fellowship (G. K. S., FT120100564) schemes.