Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses
Kheng H Tan, Christine A Seers, Stuart G Dashper, Helen L Mitchell, James S Pyke, Vincent Meuric, Nada Slakeski, Steven M Cleal, Jenny L Chambers, Malcolm J McConville, Eric C Reynolds
PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2014
Porphyromonas gingivalis and Treponema denticola are strongly associated with chronic periodontitis. These bacteria have been co-localized in subgingival plaque and demonstrated to exhibit symbiosis in growth in vitro and synergistic virulence upon co-infection in animal models of disease. Here we show that during continuous co-culture a P. gingivalis:T. denticola cell ratio of 6∶1 was maintained with a respective increase of 54% and 30% in cell numbers when compared with mono-culture. Co-culture caused significant changes in global gene expression in both species with altered expression of 184 T. denticola and 134 P. gingivalis genes. P. gingivalis genes encoding a predicted thiamine biosyn..View full abstract
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Awarded by Australian National Health and Medical Research Council Project
This work was supported by the Australian National Health and Medical Research Council Project Grant Number 1008061. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.