Journal article
Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of parkinson's disease
G Sahin, LH Thompson, S Lavisse, M Ozgur, L Rbah-Vidal, F Dollé, P Hantraye, D Kirik
Plos One | Published : 2014
Abstract
Dyskinesia is a major side effect of an otherwise effective L-DOPA treatment in Parkinson's patients. The prevailing view for the underlying presynaptic mechanism of L-DOPA-induced dyskinesia (LID) suggests that surges in dopamine (DA) via uncontrolled release from serotonergic terminals results in abnormally high level of extracellular striatal dopamine. Here we used high-sensitivity online microdialysis and PET imaging techniques to directly investigate DA release properties from serotonergic terminals both in the parkinsonian striatum and after neuronal transplantation in 6-OHDA lesioned rats. Although L-DOPA administration resulted in a drift in extracellular DA levels, we found no evide..
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Awarded by European Commission
Funding Acknowledgements
The authors would like to acknowledge the Swedish Research Council (K2009-61P-20945-03-1), Swedish Parkinson Foundation (grant no. 334/10), the European Research Council (ERC) Starting Grant (TreatPD, 242932) and European Union 6th Framework Program project Diagnostic Molecular Imaging (DiMI, LSHB-CT-2005-512146). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.