Journal article
Replication of genetic loci implicated in diabetic retinopathy
AK McAuley, JJ Wang, M Dirani, PP Connell, E Lamoureux, AW Hewitt
Investigative Ophthalmology and Visual Science | Published : 2014
Abstract
Purpose. Recent genome-wide association studies for diabetic retinopathy (DR) have identified novel single nucleotide polymorphisms (SNPs) associated with this potentially blinding disease. These markers could prove useful in risk profiling, if the association are validated by replication. To date, these associations have not been well assessed in independent cohorts. The objective of this study was to ascertain any association of these polymorphisms with advanced stages of DR. Methods. A total of 463 patients who had either type 1 (n = 46) or 2 (n = 417) diabetes were genotyped for 24 SNPs previously implicated in DR. Cases (n = 163) were defined as people with severe nonproliferative DR or..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC) Centre for Clinical Research Excellence Grant - Translational Clinical Research in Major Eye Diseases
Awarded by NHMRC Fellowships
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
Supported by the Brownless Perpetual Charitable Trust, the Diabetes Australia Research Trust, and a National Health and Medical Research Council (NHMRC) Centre for Clinical Research Excellence Grant - Translational Clinical Research in Major Eye Diseases (#529923). AKM is supported by an NHMRC Postgraduate Scholarship. JJW, EL, and AWH are supported by NHMRC Fellowships (#632909, #1045280, and #1037838, respectively). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.