Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A Pane; Nicole L Webster; Barbara S Coulson

Journal article

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A Pane, Nicole L Webster, Barbara S Coulson

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.ppat.1003998

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Abstract

It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a chronic autoimmune disease marked by infiltration of activated lymphocytes into pancreatic islets. Non-obese diabetic (NOD) mice provide a model for the human disease. Infection of adult NOD mice with rhesus monkey rotavirus (RRV) accelerates diabetes onset, without evidence of pancreatic infection. Rather, RRV spreads to the pancreatic and mesenteric lymph nodes where its association with antigen-presenting cells, including dendritic cells, induces cellular maturation. RRV infection increases levels of the class I major histocompatibility complex on B cells and pr..

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University of Melbourne Researchers

Barbara Coulson Author Microbiology and Immunology

Jessica Neil Author Microbiology and Immunology

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RESEARCH FELLOWSHIP - ASSOC PROF BARBARA COULSON

I am a virologist carrying out research to determine the mechanisms underlying rotavirus cellular tropism and the pathogenesis of rotavirus ..

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by Project Grants (509008 and 1044868) and a Senior Research Fellowship (628319) to BSC from the National Health and Medical Research Council of Australia (http://www.nhmrc.gov.au). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.