Regional brain volumes and cognition in childhood epilepsy: Does size really matter?

FA Zelko; HR Pardoe; SR Blackstone; GD Jackson; AT Berg

Journal article

Regional brain volumes and cognition in childhood epilepsy: Does size really matter?

FA Zelko, HR Pardoe, SR Blackstone, GD Jackson, AT Berg

Epilepsy Research | Published : 2014

DOI: 10.1016/j.eplepsyres.2014.02.003

Abstract

Purpose: Recent studies have correlated neurocognitive function and regional brain volumes in children with epilepsy. We tested whether brain volume differences between children with and without epilepsy explained differences in neurocognitive function. Methods: The study sample included 108 individuals with uncomplicated non-syndromic epilepsy (NSE) and 36 healthy age- and gender-matched controls. Participants received a standardized cognitive battery. Whole brain T1-weighted MRI was obtained and volumes analyzed with FreeSurfer (TM). Key findings: Total brain volume (TBV) was significantly smaller in cases. After adjustment for TBV, cases had significantly larger regional grey matter volum..

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University of Melbourne Researchers

Heath Pardoe Author

Graeme Jackson Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was funded by a grant from the National Institutes of Health, NINDS-NS-R37-31146, to Anne T. Berg, Ph.D. We wish to thank the physicians in Connecticut who allowed us to recruit and follow their patients and the many families who have participated in this project over the years.