Journal article

Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis

Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood



Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of these three types has been found to be altered in individuals at genetic risk of psychosis, and in patients with first episode psychosis (FEP) and chronic schizophrenia. This study aims at establishing whether altered OFC sulcogyral patterns were present in a large cohort of individuals at ultra high risk (UHR) for psychosis. OFC pattern type was classified and the number of posterior and intermediate sulci present on the surface of the OFC was counted. OFC sulcogyral type and the number of sulci were compared between controls (n=58) and UHR participants who trans..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

Dr S. Lavoie and Prof C. Pantelis were supported by a National Health and Medical Research Council of Australia (NHMRC) Program Grant (ID: 566529). Prof C. Pantelis was also supported by a NHMRC Senior Principal Research Fellowship (ID: 628386). Dr C. F. Bartholomeusz, Dr S. L. Whittle and Dr B. Nelson were each supported by NHMRC fellowships (567042, 1007716 and 1027532, respectively).