Journal article
Calorie intake and patient outcomes in severe acute kidney injury: Findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial
R Bellomo, A Cass, L Cole, S Finfer, M Gallagher, J Lee, S Lo, C McArthur, S McGuinness, J Myburgh, R Norton, C Scheinkestel, I Mitchell, R Ashley, J Gissane, K Malchukova, J Ranse, A Raza, K Nand, T Sara Show all
Critical Care | Published : 2014
DOI: 10.1186/cc13767
Open access
Abstract
Introduction: Current practice in the delivery of caloric intake (DCI) in patients with severe acute kidney injury (AKI) receiving renal replacement therapy (RRT) is unknown. We aimed to describe calorie administration in patients enrolled in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study and to assess the association between DCI and clinical outcomes.Methods: We performed a secondary analysis in 1456 patients from the RENAL trial. We measured the dose and evolution of DCI during treatment and analyzed its association with major clinical outcomes using multivariable logistic regression, Cox proportional hazards models, and time adjusted models.Re..
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Awarded by Health Research Council of New Zealand
Funding Acknowledgements
This study was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (Grant No 352550) and Health Research Council (HRC) of New Zealand (Grant No 06-357). Professor Alan Cass was supported by a NHMRC Senior Research Fellowship. We thank Gambro for providing discounted pricing for Haemosol (TM) dialysate and replacement fluids and the nurses in our intensive care units, our physician colleagues, and our patients and their families for the support of this trial. The founding bodies had no involvement in the design, collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study is a collaboration of the Australian and New Zealand Intensive Care Society Clinical Trials Group and the George Institute for International Health.