Engineering fluorescent poly(dopamine) capsules

X Chen; Y Yan; M Müllner; MP Van Koeverden; KF Noi; W Zhu; F Caruso

Journal article

Engineering fluorescent poly(dopamine) capsules

X Chen, Y Yan, M Müllner, MP Van Koeverden, KF Noi, W Zhu, F Caruso

Langmuir | Published : 2014

DOI: 10.1021/la4049133

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Abstract

The recent development of poly(dopamine) (PDA) capsules provides new opportunities for their application in biology and medicine. To advance the biomedical application of PDA capsules, strategies that enable the preparation of fluorescently labeled PDA (F-PDA) capsules are required, as this will allow evaluation of their cellular interactions using a range of fluorescence-based techniques. Herein, we report a facile approach for the fabrication of F-PDA capsules via the polymerization of dopamine (DA) on sacrificial templates in the presence of hydrogen peroxide (H2O2). F-PDA capsules with well-defined sizes are prepared by templating different organic and inorganic particles. The resulting ..

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University of Melbourne Researchers

Martin van Koeverden Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Discovery Early Career Researcher Award (Y.Y., DE130100488) schemes. M.M. acknowledges The University of Melbourne for a McKenzie fellowship. X.C. acknowledges The University of Melbourne for a Melbourne Research Scholarship and a Melbourne International Research Scholarship. We acknowledge Dr. Nicholas Williamson and Paul O'Donnell (Bio21 Mass Spectrometry and Proteomics Facility) for assistance with chromatography and mass spectroscopy analysis.