Journal article
The closely related CD103 dendritic cells (DCs) and lymphoid-resident CD8 DCs differ in their inflammatory functions
Z Jiao, S Bedoui, JL Brady, A Walter, M Chopin, EM Carrington, RM Sutherland, SL Nutt, Y Zhang, HJ Ko, L Wu, AM Lew, Y Zhan
Plos One | Published : 2014
Open access
Abstract
Migratory CD103+ and lymphoid-resident CD8+ dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional diversity of the two DC types is nevertheless incompletely understood. Here we reveal that upon skin infection with herpes simplex virus, migratory CD103+ DCs from draining lymph nodes were more potent at inducing Th17 cytokine production by CD4+ T cells than CD8 + DCs. This superior capacity to drive Th17 responses was also evident in CD103+ DCs from uninfected mice. Their differential potency to ind..
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Awarded by National Science Foundation
Funding Acknowledgements
This work was supported by National Health and Medical Research Council of Australia (NH&MRC) program and project grants (#575543, #637324 and #1007703), Juvenile Diabetes Research Foundation, NHMRC Independent Research Institutes Infrastructure Support Scheme grant #361646, and Victorian State Government Operational Infrastructure Support and the Australian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.