Journal article

C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to alpha-cleavage

Vanessa A Johanssen, Timothy Johanssen, Colin L Masters, Andrew F Hill, Kevin J Barnham, Steven J Collins

BIOCHEMICAL JOURNAL | PORTLAND PRESS LTD | Published : 2014

DOI: 10.1042/BJ20131378

Related Projects (3)

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NEURODEGENERATION IN THE AGING BRAIN: HOW THE PATHWAYS LEADING TO AGGREGATED PROTEIN CAUSE DISEASE

The team consists of eight highly experienced research scientists who are dedicated to solving the question of how the brain degenerates in ..

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Neurodegeneration in the aging brain: how the pathways leading to aggregated protein cause disease

The team consists of eight highly experienced research scientists who are dedicated to solving the question of how the brain degenerates in ..

Grants

Awarded by National Health and Medical Research Council

Awarded by Bethlehem Griffiths Research Foundation

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council [grant numbers 400202 and 400183] and the Bethlehem Griffiths Research Foundation [grant number 802270].

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Keywords

Amyloid-Beta-Protein
Amino Acid Sequence
Mice
Life Sciences & Biomedicine
Cell Survival
Mutant Prp
Peptide Fragments
Cells, Cultured
Cerebral Cortex
Mechanism
Prion Protein (prp)
Conformational Transitions
Fragment
Prpc Proteins
Peptide Modelling
Science & Technology
Alpha-Cleavage
Humans
Intracellular Accumulation
Prion Protein Cleavage
Animals
Mice, Inbred C57bl
Molecular Sequence Data
Mice, 129 Strain
Biochemistry & Molecular Biology
Neurotoxicity
Aggregation
Disease
Human Prion Protein