Tumor growth pattern as predictor of colorectal liver metastasis recurrence

Abstract

Background Surgical resection is the gold standard therapy for the treatment of colorectal liver metastases (CRM). The aim of this study was to investigate the impact of tumor growth patterns on disease recurrence. Methods We enrolled 91 patients who underwent CRM resection. Pathological specimens were prospectively evaluated, with particular attention given to tumor growth patterns (infiltrative vs pushing). Results Tumor recurrence was observed in 65 patients (71.4%). According to multivariate analysis, 3 or more lesions (P =.05) and the infiltrative tumor margin type (P =.05) were unique independent risk factors for recurrence. Patients with infiltrative margins had a 5-year disease-free ..