Journal article
Breast cancer risk and the BRCA1 interacting protein CTIP
KL Gorringe, DYH Choong, GJ Lindeman, JE Visvader, IG Campbell
Breast Cancer Research and Treatment | SPRINGER | Published : 2008
Abstract
Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in breast cancer risk. © 2007 Springer Science+Business Media, LLC.
Grants
Funding Acknowledgements
The authors would like to thank Heather Thorne, Danni Surace and Lynda Williams for preparing DNA, the kConFab research nurses and staff of the Familial Cancer Clinics for data collection, kConFab Central Registry staff for supplying data, and the families for their participation. kConFab is supported by the NHMRC Australia, the National Breast Cancer Foundation of Australia and the Cancer Councils of New South Wales, Queensland, South Australia, Victoria and Western Australia. This work was supported by the Victorian Breast Cancer Research Consortium.