Journal article

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones



Early life stress causes long-lasting effects on the limbic system that may be relevant to the development of mesial temporal lobe epilepsy (MTLE) and its associated psychopathology. Recent studies in rats suggest that maternal separation (MS), a model of early life stress, confers enduring vulnerability to amygdala kindling limbic epileptogenesis. However, the mechanisms underlying this remain unknown. Here, we tested whether hypothalamic-pituitary-adrenal (HPA) axis hyper-reactivity induced by MS - specifically the excessive secretion of corticosterone following a seizure - was involved in this vulnerability. In adult female rats subjected to MS from postnatal days 2-14, seizure-induced co..

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Awarded by NHMRC project

Awarded by NHMRC CDA Fellowship

Funding Acknowledgements

This research was supported by NHMRC project grants (#566544 to NJ, and #566843 to TOB, MS, MM and NJ) and an NHMRC CDA Fellowship to NJ (#628466). These sources did not contribute to the study design, in the collection, analysis or interpretation of data, the writing of the report, or the decision to submit this research paper for publication.