DYSREGULATION OF SYNAPTIC PROTEINS, DENDRITIC SPINE ABNORMALITIES AND PATHOLOGICAL PLASTICITY OF SYNAPSES AS EXPERIENCE-DEPENDENT MEDIATORS OF COGNITIVE AND PSYCHIATRIC SYMPTOMS IN HUNTINGTON'S DISEASE
J Nithianantharajah, AJ Hannan
NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2013
Huntington's disease (HD) is an autosomal dominant tandem repeat expansion disorder involving cognitive, psychiatric and motor symptoms. The expanded trinucleotide (CAG) repeat leads to an extended polyglutamine tract in the huntingtin protein and a subsequent cascade of molecular and cellular pathogenesis. One of the key features of neuropathology, which has been shown to precede the eventual loss of neurons in the cerebral cortex, striatum and other areas, are changes to synapses, including the dendritic protrusions known as spines. In this review we will focus on synapse and spine pathology in HD, including molecular and experience-dependent aspects of pathogenesis. Dendritic spine pathol..View full abstract
Awarded by ARC Future Fellowship
Awarded by EU programs
We thank past and present colleagues for useful discussions. A.J.H. is supported by an ARC Future Fellowship (FT3) and NHMRC Grants. J.N. supported by The Wellcome Trust, Genes to Cognition Program, EU programs (Project GENCODYS No. 241995, Project EUROSPIN No. 242498 and Project SYNSYS No. 242167).