Journal article
Hippocampal volume and memory and learning outcomes at 7 years in children born very preterm.
C Omizzolo, DK Thompson, SE Scratch, R Stargatt, KJ Lee, J Cheong, G Roberts, LW Doyle, PJ Anderson
Journal of the International Neuropsychological Society JINS | Published : 2013
Abstract
Using magnetic resonance imaging, this study compared hippocampal volume between 145 very preterm children and 34 children born full-term at 7 years of age. The relationship between hippocampal volume and memory and learning impairments at 7 years was also investigated. Manual hippocampal segmentation and subsequent three-dimensional volumetric analysis revealed reduced hippocampal volumes in very preterm children compared with term peers. However, this relationship did not remain after correcting for whole brain volume and neonatal brain abnormality. Contrary to expectations, hippocampal volume in the very preterm cohort was not related to memory and learning outcomes. Further research inve..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
We acknowledge the input of the entire VIBeS research team, and all the families who participated in this study. This study was funded by Australia's National Health & Medical Research Council (Project Grants (237117 & 491209), Early Career Award (1012236 to D.T.), Senior Research Fellowship (628371 to P.A.)), National Institutes of Health (HD058056), and the Victorian Government's Operational Infrastructure Support Program. The information in this manuscript and the manuscript itself has never been published either electronically or in print, and there are no conflicts of interest.