Journal article
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
J Achan, I Adam, E Arinaitwe, EA Ashley, GR Awab, MS Ba, KI Barnes, Q Bassat, S Borrmann, T Bousema, P Dahal, U D'Alessandro, TME Davis, AM Dondorp, G Dorsey, CJ Drakeley, CI Fanello, B Faye, JA Flegg, O Gaye Show all
Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Background:Dihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children. We investigated the influence of different dosing schedules on DP's clinical efficacy.Methods and Findings:A systematic search of the literature was conducted to identify all studies published between 1960 and February 2013, in which patients were enrolled and treated with DP. Principal investigators were approached and invited to share individual patient data with the WorldWide Antimalarial Resistance Network (WWARN). Data were pooled using a standardised methodology. Univariable..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
WWARN is funded by a Bill & Melinda Gates Foundation grant. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.